Booster Effect of a Natural Extract of Polypodium leucotomos (Fernblock®) That Improves the UV Barrier Function and Immune Protection Capability of Sunscreen Formulations

Background: Novel approaches to photoprotection must go beyond classical MED measurements, as discoveries on the effect of UV radiation skin paints a more complex and multi-pronged scenario with multitude cell types involved. Of these, photoimmunoprotection emerges crucial factor that protects against cancer photoaging. A novel immune parameter is enabled by precise knowledge wavelength dose solar induces photoimmunosupression. Natural substances, can play different roles in antioxidant, regulation, DNA protection well its possible ability sunscreen are new goals cosmetic industry. Objective: To analyze specific natural extract from Polypodium leucotomos (PLE, Fernblock®), part topical formulations protect photoimmunosuppression, other deleterious biological effects radiation. Methods: The PLE was analyzed including 1% (w/w) four galenic containing combinations UVB UVA organic mineral filters. In vitro sun (SPF), (UVA-PF), contact hypersensitivity (CHS), human immunoprotection (HIF) were estimated following same protocol ISO 24443:2012 for UVA-PF determination. Results: PLE-containing significantly reduced reaching skin. Combination filters increased SPF UVAPF significantly. also protection, elevating immunoprotective formulations. Conclusion: This study confirms double role photoprotection. Together activity shown previous works, absorption properties confers booster when it supplemented sunscreens increasing not only at level erythema permanent pigment darkening but two factors.